Cross-reactivity of HLA-B*1801-restricted T-lymphocyte clones with target cells expressing variants of the human cytomegalovirus 72kDa-IE1 protein.
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ABSTRACT:
SUBMITTER: Prod'homme V
PROVIDER: S-EPMC156178 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
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Cross-reactivity of HLA-B*1801-restricted T-lymphocyte clones with target cells expressing variants of the human cytomegalovirus 72kDa-IE1 protein.
Prod'homme Virginie V Retière Christelle C Valtcheva Ralitza R Bonneville Marc M Hallet Marie-Martine MM
Journal of virology 20030601 12
The impact of natural polymorphism in a cytomegalovirus-dominant HLA-B(*)1801-restricted epitope, IE1(199-206), on the specific responses of T-cell clones was assessed by measuring their cytolytic activity against target cells expressing mutated recombinant IE1 proteins. Our results suggest an in vivo selection of T lymphocytes that cross-react with multiple IE1 variants. ...[more]
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