Ontology highlight
ABSTRACT:
SUBMITTER: Miller BC
PROVIDER: S-EPMC156353 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Miller Bonnie C BC Eckman Elizabeth A EA Sambamurti Kumar K Dobbs Nicole N Chow K Martin KM Eckman Christopher B CB Hersh Louis B LB Thiele Dwain L DL
Proceedings of the National Academy of Sciences of the United States of America 20030505 10
Factors that elevate amyloid-beta (Abeta) peptide levels are associated with an increased risk for Alzheimer's disease. Insulysin has been identified as one of several proteases potentially involved in Abeta degradation based on its hydrolysis of Abeta peptides in vitro. In this study, in vivo levels of brain Abeta40 and Abeta42 peptides were found to be increased significantly (1.6- and 1.4-fold, respectively) in an insulysin-deficient gene-trap mouse model. A 6-fold increase in the level of th ...[more]