Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjects.
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ABSTRACT:
SUBMITTER: DeJesus E
PROVIDER: S-EPMC1563559 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
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Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjects.
DeJesus Edwin E Piliero Peter J PJ Summers Kim K Wire Mary Beth MB Stein Daniel S DS Masterman Amanda A Lou Yu Y Min Sherene S SS Shelton Mark J MJ
Antimicrobial agents and chemotherapy 20060901 9
Fosamprenavir (FPV) with and without ritonavir (RTV) was added to the antiretroviral regimens of human immunodeficiency virus-infected subjects receiving nevirapine (NVP) to evaluate this drug interaction. Significant reductions in plasma amprenavir exposure (25 to 35%) were observed following coadministration of 1,400 mg of FPV twice a day (BID) and 200 mg of NVP BID. A regimen of 700 mg of FPV BID plus 100 mg of RTV BID may be coadministered with NVP without dose adjustment. ...[more]
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