Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC1563835 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Xu Xiaoling X Zhai Yujia Y Sun Fei F Lou Zhiyong Z Su Dan D Xu Yuanyuan Y Zhang Rongguang R Joachimiak Andrzej A Zhang Xuejun C XC Bartlam Mark M Rao Zihe Z
Journal of virology 20060801 16
The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded nonstructural proteins (nsp) plays a vital role during initial and intermediate phases of the viral life cycle. The crystal structure of mouse hepatitis virus strain A59 (MHV-A59) nsp15 is reported at 2.15-A resolution. nsp15 is an XendoU endoribonuclease and is the first one from this family to have its structure unveiled. The MHV-A59 nsp15 monomer structure has a novel protein fold. Two nsp15 trimers ...[more]