Ontology highlight
ABSTRACT:
SUBMITTER: Botten J
PROVIDER: S-EPMC1563871 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Botten Jason J Alexander Jeff J Pasquetto Valerie V Sidney John J Barrowman Polly P Ting Joey J Peters Bjoern B Southwood Scott S Stewart Barbara B Rodriguez-Carreno Maria P MP Mothe Bianca B Whitton J Lindsay JL Sette Alessandro A Buchmeier Michael J MJ
Journal of virology 20060901 17
Recovery from Lassa virus (LASV) infection usually precedes the appearance of neutralizing antibodies, indicating that cellular immunity plays a primary role in viral clearance. To date, the role of LASV-specific CD8(+) T cells has not been evaluated in humans. To facilitate such studies, we utilized a predictive algorithm to identify candidate HLA-A2 supertype epitopes from the LASV nucleoprotein and glycoprotein precursor (GPC) genes. We identified three peptides (GPC(42-50), GLVGLVTFL; GPC(60 ...[more]