Ontology highlight
ABSTRACT:
SUBMITTER: Pace C
PROVIDER: S-EPMC1563905 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Pace Craig C Keller Jean J Nolan David D James Ian I Gaudieri Silvana S Moore Corey C Mallal Simon S
Journal of virology 20060901 18
APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G-->A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known. Here, we describe a population level analysis of HIV-1 hypermutation in [corrected] clade B proviral DNA sequences (n = 127). G-->A hypermutation conforming to expected APOBEC3G polynucleotide sequence preferences was inferred in 9.4% (n = 12) of the HIV-1 sequ ...[more]