Ontology highlight
ABSTRACT:
SUBMITTER: Poet M
PROVIDER: S-EPMC1564226 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Poët Mallorie M Kornak Uwe U Schweizer Michaela M Zdebik Anselm A AA Scheel Olaf O Hoelter Sabine S Wurst Wolfgang W Schmitt Anja A Fuhrmann Jens C JC Planells-Cases Rosa R Mole Sara E SE Hübner Christian A CA Jentsch Thomas J TJ
Proceedings of the National Academy of Sciences of the United States of America 20060901 37
Mammalian CLC proteins function as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers and are present in the plasma membrane and intracellular vesicles. We now show that the ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression in dorsal root ganglia. ClC-6 colocalized with markers for late endosomes in neuronal cell bodies. The disruption of ClC-6 in mice reduced their pain sensitivity and caused moderate ...[more]