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Combined histomorphometric and gene-expression profiling applied to toxicology.

ABSTRACT: We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl4)-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis.

SUBMITTER: Kriete A

PROVIDER: S-EPMC156588 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature

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Combined histomorphometric and gene-expression profiling applied to toxicology.

Kriete Andres A Anderson Mary K MK Love Brad B Freund John J Caffrey James J JJ Young M Brook MB Sendera Timothy J TJ Magnuson Scott R SR Braughler J Mark JM

Genome biology 20030430 5

We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl4)-treated rats, and demonstrates correlations between specific genes and tissue structure ...[more]

PMID: 12734012

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