Ontology highlight
ABSTRACT:
SUBMITTER: Jones S
PROVIDER: S-EPMC156721 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Nucleic acids research 20030601 11
This work describes a method for predicting DNA binding function from structure using 3-dimensional templates. Proteins that bind DNA using small contiguous helix-turn-helix (HTH) motifs comprise a significant number of all DNA-binding proteins. A structural template library of seven HTH motifs has been created from non-homologous DNA-binding proteins in the Protein Data Bank. The templates were used to scan complete protein structures using an algorithm that calculated the root mean squared dev ...[more]