Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC1567701 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Zhao Yaofeng Y Pan-Hammarström Qiang Q Yu Shuyang S Wertz Nancy N Zhang Xiaofeng X Li Ning N Butler John E JE Hammarström Lennart L
Proceedings of the National Academy of Sciences of the United States of America 20060728 32
Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by C(phi)), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a hinge exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3' of C(mu), that shares featur ...[more]