Ontology highlight
ABSTRACT:
SUBMITTER: Muench SP
PROVIDER: S-EPMC1567884 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Muench Stephen P SP Xu Ling L Sedelnikova Svetlana E SE Rice David W DW
Proceedings of the National Academy of Sciences of the United States of America 20060807 33
The structure of a Bacillus subtilis YphC/GDP complex shows that it contains two GTPase domains that pack against a central domain whose fold resembles that of an RNA binding KH-domain. Comparisons of this structure to that of a homologue in Thermotoga maritima reveals a dramatic rearrangement in the position of the N-terminal GTPase domain with a shift of up to 60 A and the formation of a totally different interface to the central domain. This rearrangement appears to be triggered by conformati ...[more]