Ontology highlight
ABSTRACT:
SUBMITTER: Kaufmann B
PROVIDER: S-EPMC1567891 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Kaufmann Bärbel B Nybakken Grant E GE Chipman Paul R PR Zhang Wei W Diamond Michael S MS Fremont Daved H DH Kuhn Richard J RJ Rossmann Michael G MG
Proceedings of the National Academy of Sciences of the United States of America 20060808 33
Flaviviruses, such as West Nile virus (WNV), are significant human pathogens. The humoral immune response plays an important role in the control of flavivirus infection and disease. The structure of WNV complexed with the Fab fragment of the strongly neutralizing mAb E16 was determined to 14.5-Angstrom resolution with cryo-electron microscopy. E16, an antibody with therapeutic potential, binds to domain III of the WNV envelope glycoprotein. Because of steric hindrance, Fab E16 binds to only 120 ...[more]