Ontology highlight
ABSTRACT:
SUBMITTER: Nath R
PROVIDER: S-EPMC1569872 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Nath Rahul R Mant Christine A CA Kell Barbara B Cason John J Bible Jon M JM
Cancer cell international 20060809
<h4>Background</h4>Human papillomavirus type 16 (HPV-16) E5 protein co-operates with epidermal growth factor to stimulate mitogenesis of murine fibroblasts. Currently, little is known about which viral amino acids are involved in this process. Using sequence variants of HPV-16 E5 we have investigated their effects upon E5 transcription, cell-cycling and cell-growth of murine fibroblasts.<h4>Results</h4>We demonstrate that: (i) introduction of Thr64 into the reference E5 sequence of HPV-16 abroga ...[more]