Ontology highlight
ABSTRACT:
SUBMITTER: Smithrud DB
PROVIDER: S-EPMC15735 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
Smithrud D B DB Benkovic P A PA Benkovic S J SJ Roberts V V Liu J J Neagu I I Iwama S S Phillips B W BW Smith A B AB Hirschmann R R
Proceedings of the National Academy of Sciences of the United States of America 20000201 5
Cyclic hexapeptides represent a class of compounds with important, diverse biological activities. We report herein that the antibody 16G3 catalyzes the cyclization of d-Trp-Gly-Pal-Pro-Gly-Phe small middle dotp-nitrophenyl ester (8a) to give c-(d-Trp-Gly-Pal-Pro-Gly-l-Phe) (11a). The antibody does not, however, catalyze either epimerization or hydrolysis. The resulting rate enhancement of the cyclization by 16G3 (22-fold) was sufficient to form the desired product in greater than 90% yield. In a ...[more]