Ontology highlight
ABSTRACT:
SUBMITTER: da Costa KA
PROVIDER: S-EPMC1574369 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
da Costa Kerry-Ann KA Kozyreva Olga G OG Song Jiannan J Galanko Joseph A JA Fischer Leslie M LM Zeisel Steven H SH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701 9
Humans eating diets deficient in the essential nutrient choline can develop organ dysfunction. We hypothesized that common single nucleotide polymorphisms (SNPs) in genes involved in choline metabolism influence the dietary requirement of this nutrient. Fifty-seven humans were fed a low choline diet until they developed organ dysfunction or for up to 42 days. We tested DNA SNPs for allelic association with susceptibility to developing organ dysfunction associated with choline deficiency. We iden ...[more]