Ontology highlight
ABSTRACT:
SUBMITTER: Ng HL
PROVIDER: S-EPMC15749 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
Ng H L HL Kopka M L ML Dickerson R E RE
Proceedings of the National Academy of Sciences of the United States of America 20000201 5
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition. ...[more]