Dataset Information

Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.

ABSTRACT:

Objectives

To examine whether infertile couples (with a time to pregnancy of > 12 months), who conceive naturally or after treatment, give birth to children with an increased prevalence of congenital malformations.

Design

Longitudinal study.

Setting

Danish national birth cohort.

Participants

Three groups of liveborn children and their mothers: 50,897 singletons and 1366 twins born of fertile couples (time to pregnancy < or = 12 months), 5764 singletons and 100 twins born of infertile couples who conceived naturally (time to pregnancy > 12 months), and 4588 singletons and 1690 twins born after infertility treatment.

Main outcome measures

Prevalence of congenital malformations determined from hospital discharge diagnoses.

Results

Compared with singletons born of fertile couples, singletons born of infertile couples who conceived naturally or after treatment had a higher prevalence of congenital malformations-hazard ratios 1.20 (95% confidence interval 1.07 to 1.35) and 1.39 (1.23 to 1.57). The overall prevalence of congenital malformations increased with increasing time to pregnancy. When the analysis was restricted to singletons born of infertile couples, babies born after treatment had an increased prevalence of genital organ malformations (hazard ratio 2.32, 1.24 to 4.35) compared with babies conceived naturally. No significant differences existed in the overall prevalence of congenital malformations among twins.

Conclusions

Hormonal treatment for infertility may be related to the occurrence of malformations of genital organs, but our results suggest that the reported increased prevalence of congenital malformations seen in singletons born after assisted reproductive technology is partly due to the underlying infertility or its determinants. The association between untreated infertility and congenital malformations warrants further examination.

SUBMITTER: Zhu JL

PROVIDER: S-EPMC1584372 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature

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Publications

Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.

Zhu Jin Liang JL Basso Olga O Obel Carsten C Bille Camilla C Olsen Jørn J

BMJ (Clinical research ed.) 20060807 7570

<h4>Objectives</h4>To examine whether infertile couples (with a time to pregnancy of > 12 months), who conceive naturally or after treatment, give birth to children with an increased prevalence of congenital malformations.<h4>Design</h4>Longitudinal study.<h4>Setting</h4>Danish national birth cohort.<h4>Participants</h4>Three groups of liveborn children and their mothers: 50,897 singletons and 1366 twins born of fertile couples (time to pregnancy < or = 12 months), 5764 singletons and 100 twins ...[more]

PMID: 16893903

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Dataset Information

Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.

Objectives

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.

Similar Datasets

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