Ontology highlight
ABSTRACT:
SUBMITTER: Clements CM
PROVIDER: S-EPMC1586179 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Clements Casey M CM McNally Richard S RS Conti Brian J BJ Mak Tak W TW Ting Jenny P-Y JP
Proceedings of the National Academy of Sciences of the United States of America 20061002 41
DJ-1/PARK7, a cancer- and Parkinson's disease (PD)-associated protein, protects cells from toxic stresses. However, the functional basis of this protection has remained elusive. We found that loss of DJ-1 leads to deficits in NQO1 [NAD(P)H quinone oxidoreductase 1], a detoxification enzyme. This deficit is attributed to a loss of Nrf2 (nuclear factor erythroid 2-related factor), a master regulator of antioxidant transcriptional responses. DJ-1 stabilizes Nrf2 by preventing association with its i ...[more]