The use of gene clusters to infer functional coupling.
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ABSTRACT:
SUBMITTER: Overbeek R
PROVIDER: S-EPMC15866 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
Publications
The use of gene clusters to infer functional coupling.
Overbeek R R Fonstein M M D'Souza M M Pusch G D GD Maltsev N N
Proceedings of the National Academy of Sciences of the United States of America 19990301 6
Previously, we presented evidence that it is possible to predict functional coupling between genes based on conservation of gene clusters between genomes. With the rapid increase in the availability of prokaryotic sequence data, it has become possible to verify and apply the technique. In this paper, we extend our characterization of the parameters that determine the utility of the approach, and we generalize the approach in a way that supports detection of common classes of functionally coupled ...[more]
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