Ontology highlight
ABSTRACT:
SUBMITTER: Seki M
PROVIDER: S-EPMC1592785 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Seki Masayuki M Nakagawa Takayuki T Seki Takahiko T Kato Genta G Tada Shusuke S Takahashi Yuriko Y Yoshimura Akari A Kobayashi Takayuki T Aoki Ayako A Otsuki Makoto M Habermann Felix A FA Tanabe Hideyuki H Ishii Yutaka Y Enomoto Takemi T
Molecular and cellular biology 20060801 16
Bloom's syndrome (BS) is an autosomal disorder characterized by predisposition to a wide variety of cancers. The gene product whose mutation leads to BS is the RecQ family helicase BLM, which forms a complex with DNA topoisomerase IIIalpha (Top3alpha). However, the physiological relevance of the interaction between BLM and Top3alpha within the cell remains unclear. We show here that Top3alpha depletion causes accumulation of cells in G2 phase, enlargement of nuclei, and chromosome gaps and break ...[more]