A glucose sensor in Candida albicans.
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ABSTRACT:
SUBMITTER: Brown V
PROVIDER: S-EPMC1595344 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
A glucose sensor in Candida albicans.
Brown Victoria V Sexton Jessica A JA Johnston Mark M
Eukaryotic cell 20061001 10
The Hgt4 protein of Candida albicans (orf19.5962) is orthologous to the Snf3 and Rgt2 glucose sensors of Saccharomyces cerevisiae that govern sugar acquisition by regulating the expression of genes encoding hexose transporters. We found that HGT4 is required for glucose induction of the expression of HGT12, HXT10, and HGT7, which encode apparent hexose transporters in C. albicans. An hgt4Delta mutant is defective for growth on fermentable sugars, which is consistent with the idea that Hgt4 is a ...[more]
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