Ontology highlight
ABSTRACT:
SUBMITTER: Vicogne J
PROVIDER: S-EPMC1595425 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Vicogne Jérôme J Vollenweider Daniel D Smith Jeffery R JR Huang Ping P Frohman Michael A MA Pessin Jeffrey E JE
Proceedings of the National Academy of Sciences of the United States of America 20060925 40
Insulin-stimulated glucose uptake requires the fusion of GLUT4 transporter-containing vesicles with the plasma membrane, a process that depends on the SNARE (soluble N-ethylmaleimide-sensitive fusion factor attachment receptor) proteins VAMP2 (vesicle-associated membrane protein 2) and syntaxin 4 (Stx4)/SNAP23 (soluble N-ethylmaleimide-sensitive fusion factor attachment protein 23). Efficient SNARE-dependent fusion has been shown in many settings in vivo to require the generation of both phospha ...[more]