Ontology highlight
ABSTRACT:
SUBMITTER: Egger G
PROVIDER: S-EPMC1599915 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Egger Gerda G Jeong Shinwu S Escobar Sonia G SG Cortez Connie C CC Li Tony W H TW Saito Yoshimasa Y Yoo Christine B CB Jones Peter A PA Liang Gangning G
Proceedings of the National Academy of Sciences of the United States of America 20060908 38
Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the human cancer cell line HCT116 was not lethal and caused only minor decreases in methylation. Here, we report the identification of a truncated DNMT1 protein, which was generated by the disruption of DNMT1 in HCT116 cells. The truncated protein, which had parts of the regulatory N-terminal domain del ...[more]