Ontology highlight
ABSTRACT:
SUBMITTER: de Waard V
PROVIDER: S-EPMC1606614 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
de Waard Vivian V Arkenbout E Karin EK Vos Mariska M Mocking Astrid I M AI Niessen Hans W M HW Stooker Wim W de Mol Bas A J M BA Quax Paul H A PH Bakker Erik N T P EN VanBavel Ed E Pannekoek Hans H de Vries Carlie J M CJ
The American journal of pathology 20060601 6
In coronary artery bypass surgery, the patency of arterial grafts is higher than that of venous grafts because of vein-graft disease, which involves excessive proliferation of venous smooth muscle cells (SMCs) and subsequent accelerated atherosclerosis. We studied the function of TR3 nuclear orphan receptor (TR3) in the early response of SMCs to mechanical strain, a major initiator of vein-graft disease. We demonstrate that TR3 expression is induced in human saphenous vein segments exposed ex vi ...[more]