Ontology highlight
ABSTRACT:
SUBMITTER: Saika S
PROVIDER: S-EPMC1606617 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Saika Shizuya S Ikeda Kazuo K Yamanaka Osamu O Flanders Kathleen C KC Okada Yuka Y Miyamoto Takeshi T Kitano Ai A Ooshima Akira A Nakajima Yuji Y Ohnishi Yoshitaka Y Kao Winston W-Y WW
The American journal of pathology 20060601 6
Animal cornea is an avascular transparent tissue that is suitable for research on wound healing-related scarring and neovascularization. Here we show that loss of tumor necrosis factor alpha (TNFalpha) potentiates the undesirable, pathogenic response of wound healing in an alkali-burned cornea in mice. Excessive invasion of macrophages and subsequent formation of a vascularized scar tissue were much more marked in TNFalpha-null knockout (KO) mice than in wild-type mice. Such an unfavorable outco ...[more]