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Reactivity of (1-->3)-beta-d-glucan assay with commonly used intravenous antimicrobials.

ABSTRACT: Forty-four intravenous antimicrobials were tested for the presence of (1-->3)-beta-d-glucan (BG). Colistin, ertapenem, cefazolin, trimethoprim-sulfamethoxazole, cefotaxime, cefepime, and ampicillin-sulbactam tested positive for BG at reconstituted-vial concentrations but not when diluted to usual maximum plasma concentrations. False-positive BG assays may occur when some antimicrobials are administered; however, this needs to be confirmed.

SUBMITTER: Marty FM

PROVIDER: S-EPMC1610103 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature

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Reactivity of (1-->3)-beta-d-glucan assay with commonly used intravenous antimicrobials.

Marty Francisco M FM Lowry Colleen M CM Lempitski Steven J SJ Kubiak David W DW Finkelman Malcolm A MA Baden Lindsey R LR

Antimicrobial agents and chemotherapy 20061001 10

Forty-four intravenous antimicrobials were tested for the presence of (1-->3)-beta-d-glucan (BG). Colistin, ertapenem, cefazolin, trimethoprim-sulfamethoxazole, cefotaxime, cefepime, and ampicillin-sulbactam tested positive for BG at reconstituted-vial concentrations but not when diluted to usual maximum plasma concentrations. False-positive BG assays may occur when some antimicrobials are administered; however, this needs to be confirmed. ...[more]

PMID: 17005829

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