Ontology highlight
ABSTRACT:
SUBMITTER: Heyer WD
PROVIDER: S-EPMC1616967 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Heyer Wolf-Dietrich WD Li Xuan X Rolfsmeier Michael M Zhang Xiao-Ping XP
Nucleic acids research 20060825 15
Homologous recombination (HR) is a ubiquitous cellular pathway that mediates transfer of genetic information between homologous or near homologous (homeologous) DNA sequences. During meiosis it ensures proper chromosome segregation in the first division. Moreover, HR is critical for the tolerance and repair of DNA damage, as well as in the recovery of stalled and broken replication forks. Together these functions preserve genomic stability and assure high fidelity transmission of the genetic mat ...[more]