Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway.
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ABSTRACT:
SUBMITTER: Carroll KD
PROVIDER: S-EPMC1617261 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway.
Carroll Kyla Driscoll KD Bu Wei W Palmeri Diana D Spadavecchia Sophia S Lynch Stephen J SJ Marras Salvatore A E SA Tyagi Sanjay S Lukac David M DM
Journal of virology 20061001 19
Kaposi's sarcoma-associated herpesvirus (KSHV) lytic switch protein, Rta, is a ligand-independent inducer of the Notch signal transduction pathway, and KSHV cannot reactivate from latency in cells null for the Notch target protein RBP-Jk. Here we show that Rta promotes DNA binding of RBP-Jk, a mechanism that is fundamentally different from that established for the RBP-Jk-activating proteins, Notch intracellular domain (NICD) and Epstein-Barr virus EBNA2. Although constitutively active RBP-Jk and ...[more]
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