Ontology highlight
ABSTRACT:
SUBMITTER: Bowick GC
PROVIDER: S-EPMC1617297 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Bowick Gavin C GC Fennewald Susan M SM Elsom Barry L BL Aronson Judith F JF Luxon Bruce A BA Gorenstein David G DG Herzog Norbert K NK
Journal of virology 20061001 20
The family Arenaviridae includes several National Institutes of Allergy and Infections Diseases category A select agents which cause hemorrhagic fever. There are few vaccines available, and treatment is limited to ribavirin, which varies in efficacy. Development of new antiviral compounds has been hindered by a lack of understanding of the molecular basis of pathogenesis. We used two variants of Pichinde virus, one attenuated and one virulent in the guinea pig model, to delineate the host determ ...[more]