Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
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ABSTRACT:
SUBMITTER: Okamoto T
PROVIDER: S-EPMC1618089 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Okamoto Toru T Nishimura Yorihiro Y Ichimura Tohru T Suzuki Kensuke K Miyamura Tatsuo T Suzuki Tetsuro T Moriishi Kohji K Matsuura Yoshiharu Y
The EMBO journal 20061005 20
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a component of viral replicase and is well known to modulate the functions of several host proteins. Here, we show that NS5A specifically interacts with FKBP8, a member of the FK506-binding protein family, but not with other homologous immunophilins. Three sets of tetratricopeptide repeats in FKBP8 are responsible for interactions with NS5A. The siRNA-mediated knockdown of FKBP8 in a human hepatoma cell line harboring an HCV RNA replicon ...[more]
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