Ontology highlight
ABSTRACT:
SUBMITTER: Garmory HS
PROVIDER: S-EPMC162028 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Infection and immunity 20030701 7
Protective immunity against infection with Bacillus anthracis is almost entirely based on a response to the protective antigen (PA), the binding moiety for the two other toxin components. We cloned the PA gene into an auxotrophic mutant of Salmonella enterica serovar Typhimurium as a fusion with the signal sequence of the hemolysin (Hly) A gene of Escherichia coli to allow the export of PA via the Hly export system. To stabilize the export cassette, it was also integrated into the chromosome of ...[more]