Ontology highlight
ABSTRACT:
SUBMITTER: Buettner R
PROVIDER: S-EPMC16216 | biostudies-literature | 2000 Mar
REPOSITORIES: biostudies-literature
Buettner R R Papoutsoglou G G Scemes E E Spray D C DC Dermietzel R R
Proceedings of the National Academy of Sciences of the United States of America 20000301 7
Voltage-dependent anion channels (VDACs) are pore-forming proteins (porins) that form the major pathway for movement of adenine nucleotides through the outer mitochondrial membrane. Electrophysiological studies indicate that VDAC-like channel activity is also prevalent in the cell membranes of many mammalian cells. However, the multitopological localization of porins outside the mitochondrion has remained an extremely controversial issue. Herein, we show that usage of two alternative first exons ...[more]