Ontology highlight
ABSTRACT:
SUBMITTER: Belanger LF
PROVIDER: S-EPMC162209 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Bélanger Louis-François LF Roy Sophie S Tremblay Michel M Brott Barbara B Steff Ann-Muriel AM Mourad Walid W Hugo Patrice P Erikson Raymond R Charron Jean J
Molecular and cellular biology 20030701 14
MEK is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase upon agonist binding to receptors. The ERK/MAP kinase cascade is involved in cell fate determination in many organisms. In mammals, this pathway is proposed to regulate cell growth and differentiation. Genetic studies have shown that although a single Mek gene is present in Caenorhabditis elegans, Drosophila melanogaster, and Xenopus laevis, two Mek homologs, Mek ...[more]