Ontology highlight
ABSTRACT:
SUBMITTER: Thumkeo D
PROVIDER: S-EPMC162229 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Thumkeo Dean D Keel Jeongsin J Ishizaki Toshimasa T Hirose Masaya M Nonomura Kimiko K Oshima Hiroko H Oshima Masanobu M Taketo Makoto M MM Narumiya Shuh S
Molecular and cellular biology 20030701 14
Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. However, in vivo functions of each ROCK isoform remain largely unknown. We generated mice deficient in ROCK-II by gene targeting. ROCK-II(-/-) embryos were found at the expected Mendelian frequency until 13.5 days postcoitum, but approximately 90% died thereafter in utero. ROCK-II(-/-) mice of both genders that survived were born runts, subsequently d ...[more]