Ontology highlight
ABSTRACT:
SUBMITTER: Wroe SF
PROVIDER: S-EPMC16241 | biostudies-literature | 2000 Mar
REPOSITORIES: biostudies-literature
Wroe S F SF Kelsey G G Skinner J A JA Bodle D D Ball S T ST Beechey C V CV Peters J J Williamson C M CM
Proceedings of the National Academy of Sciences of the United States of America 20000301 7
The Gnas locus in distal mouse chromosome (Chr) 2 is emerging as a complex genomic region. It contains three imprinted genes in the order Nesp-Gnasxl-Gnas. Gnas encodes a G protein alpha-subunit, and Nesp and Gnasxl encode proteins of unknown function expressed in neuroendocrine tissue. Together, these genes form a single transcription unit because transcripts of Nesp and Gnasxl are alternatively spliced onto exon 2 of Gnas. Nesp and Gnasxl are expressed from opposite parental alleles, with Nesp ...[more]