'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs.
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ABSTRACT:
SUBMITTER: Elton D
PROVIDER: S-EPMC1626216 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Publications
'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs.
Elton Debra D Amorim Maria Joao MJ Medcalf Liz L Digard Paul P
Biology letters 20050601 2
Many viruses exploit cellular polarity to constrain the assembly and release of progeny virions to a desired surface. Influenza virus particles are released only from the apical surface of epithelial cells and this polarization is partly owing to specific targeting of the viral membrane proteins to the apical plasma membrane. The RNA genome of the virus is transcribed and replicated in the nucleus, necessitating nuclear export of the individual ribonucleoprotein (RNP) segments before they can be ...[more]
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