Ontology highlight
ABSTRACT:
SUBMITTER: Nowak D
PROVIDER: S-EPMC1633823 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Nowak Daniel D Mossner Maximilian M Baldus Claudia D CD Hopfer Olaf O Thiel Eckhard E Hofmann Wolf-Karsten WK
International journal of medical sciences 20061026 4
hCDC4 (FBW7, FBXW7) is a new potential tumor suppressor gene which provides substrate specificity for SCF (Skp-Cullin-F-box) ubiquitin ligases and thereby regulates the degradation of potent oncogenes such as cyclin E, Myc, c-Jun and Notch. Mutations in the hCDC4 gene have been found in several solid tumors such as pancreas, colorectal or endometrial cancer. We carried out a mutation analysis of the hCDC4 gene in 35 samples of patients with Acute Myeloid Leukemia (AML) to elucidate a possible ro ...[more]