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Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.

ABSTRACT: This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.

SUBMITTER: Williams KD

PROVIDER: S-EPMC1635102 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature

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Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.

Williams Karen D KD Busto Macarena M Suster Maximiliano L ML So Anthony K-C AK Ben-Shahar Yehuda Y Leevers Sally J SJ Sokolowski Marla B MB

Proceedings of the National Academy of Sciences of the United States of America 20061016 43

This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. ...[more]

PMID: 17043223

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