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Novel streptomycin resistance gene from Mycobacterium fortuitum.

ABSTRACT: We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.

SUBMITTER: Ramon-Garcia S 

PROVIDER: S-EPMC1635185 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature

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Novel streptomycin resistance gene from Mycobacterium fortuitum.

Ramón-García Santiago S   Otal Isabel I   Martín Carlos C   Gómez-Lus Rafael R   Aínsa José A JA  

Antimicrobial agents and chemotherapy 20060905 11

We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates. ...[more]

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