Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
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ABSTRACT:
SUBMITTER: Chau AS
PROVIDER: S-EPMC1635193 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Publications
Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
Chau Andrew S AS Chen Guodong G McNicholas Paul M PM Mann Paul A PA
Antimicrobial agents and chemotherapy 20060911 11
Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole. ...[more]
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