Ontology highlight
ABSTRACT:
SUBMITTER: Wen W
PROVIDER: S-EPMC1635351 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Wen Wenyu W Chen Lu L Wu Hao H Sun Xin X Zhang Mingjie M Banfield David K DK
Molecular biology of the cell 20060719 10
Using nuclear magnetic resonance spectroscopy, we establish that the N-terminal domain of the yeast vacuolar R-SNARE Nyv1p adopts a longin-like fold similar to those of Sec22b and Ykt6p. Nyv1p is sorted to the limiting membrane of the vacuole via the adaptor protein (AP)3 adaptin pathway, and we show that its longin domain is sufficient to direct transport to this location. In contrast, we found that the longin domains of Sec22p and Ykt6p were not sufficient to direct their localization. A YXX p ...[more]