Ontology highlight
ABSTRACT:
SUBMITTER: Partridge MA
PROVIDER: S-EPMC1635363 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Partridge Michael A MA Marcantonio Eugene E EE
Molecular biology of the cell 20060719 10
Integrin receptors, and associated cytoplasmic proteins mediate adhesion, cell signaling and connections to the cytoskeleton. Using fluorescent protein chimeras, we analyzed initial integrin adhesion in spreading fibroblasts with Total Internal Reflection Fluorescence (TIRF) microscopy. Surprisingly, sequential radial projection of integrin and actin containing filopodia formed the initial cell-matrix contacts. These Cdc42-dependent, integrin-containing projections recruited cytoplasmic focal ad ...[more]