Ontology highlight
ABSTRACT:
SUBMITTER: Shi G
PROVIDER: S-EPMC1635441 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Shi Guoli G Chang Dau-Yin DY Cheng Chih-Chien CC Guan Xin X Venclovas Ceslovas C Lu A-Lien AL
The Biochemical journal 20061101 1
The MYH (MutY glycosylase homologue) increases replication fidelity by removing adenines or 2-hydroxyadenine misincorporated opposite GO (7,8-dihydro-8-oxo-guanine). The 9-1-1 complex (Rad9, Rad1 and Hus1 heterotrimer complex) has been suggested as a DNA damage sensor. Here, we report that hMYH (human MYH) interacts with hHus1 (human Hus1) and hRad1 (human Rad1), but not with hRad9. In addition, interactions between MYH and the 9-1-1 complex, from both the fission yeast Schizosaccharomyces pombe ...[more]