Ontology highlight
ABSTRACT:
SUBMITTER: Harrison MM
PROVIDER: S-EPMC1636532 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Harrison Melissa M MM Ceol Craig J CJ Lu Xiaowei X Horvitz H Robert HR
Proceedings of the National Academy of Sciences of the United States of America 20061030 45
The Caenorhabditis elegans synthetic multivulva (synMuv) genes act redundantly to antagonize the specification of vulval cell fates, which are promoted by an RTK/Ras pathway. At least 26 synMuv genes have been genetically identified, several of which encode proteins with homologs that act in chromatin remodeling or transcriptional repression. Here we report the molecular characterization of two synMuv genes, lin-37 and lin-54. We show that lin-37 and lin-54 encode proteins in a complex with at l ...[more]