Ontology highlight
ABSTRACT:
SUBMITTER: Zhang G
PROVIDER: S-EPMC1636540 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Zhang Guangjun G Cohn Martin J MJ
Proceedings of the National Academy of Sciences of the United States of America 20061031 45
The origin of vertebrates was defined by evolution of a skeleton; however, little is known about the developmental mechanisms responsible for this landmark evolutionary innovation. In jawed vertebrates, cartilage matrix consists predominantly of type II collagen (Col2alpha1), whereas that of jawless fishes has long been thought to be noncollagenous. We recently showed that Col2alpha1 is present in lamprey cartilage, indicating that type II collagen-based cartilage evolved earlier than previously ...[more]