Ontology highlight
ABSTRACT:
SUBMITTER: Onohara N
PROVIDER: S-EPMC1636614 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Onohara Naoya N Nishida Motohiro M Inoue Ryuji R Kobayashi Hiroyuki H Sumimoto Hideki H Sato Yoji Y Mori Yasuo Y Nagao Taku T Kurose Hitoshi H
The EMBO journal 20061102 22
Angiotensin (Ang) II participates in the pathogenesis of heart failure through induction of cardiac hypertrophy. Ang II-induced hypertrophic growth of cardiomyocytes is mediated by nuclear factor of activated T cells (NFAT), a Ca(2+)-responsive transcriptional factor. It is believed that phospholipase C (PLC)-mediated production of inositol-1,4,5-trisphosphate (IP(3)) is responsible for Ca(2+) increase that is necessary for NFAT activation. However, we demonstrate that PLC-mediated production of ...[more]