Ontology highlight
ABSTRACT:
SUBMITTER: De Domenico I
PROVIDER: S-EPMC1636618 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
De Domenico Ivana I Vaughn Michael B MB Li Liangtao L Bagley Dustin D Musci Giovanni G Ward Diane M DM Kaplan Jerry J
The EMBO journal 20061102 22
Ferritin is a cytosolic molecule comprised of subunits that self-assemble into a nanocage capable of containing up to 4500 iron atoms. Iron stored within ferritin can be mobilized for use within cells or exported from cells. Expression of ferroportin (Fpn) results in export of cytosolic iron and ferritin degradation. Fpn-mediated iron loss from ferritin occurs in the cytosol and precedes ferritin degradation by the proteasome. Depletion of ferritin iron induces the monoubiquitination of ferritin ...[more]