Ontology highlight
ABSTRACT:
SUBMITTER: Uhlirova M
PROVIDER: S-EPMC1636619 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Uhlirova Mirka M Bohmann Dirk D
The EMBO journal 20061102 22
Loss of the epithelial polarity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to induce malignant tumors. Such mutant tissue overproliferates, resists apoptosis, leaves its place of origin and invades other organs, ultimately causing lethality. We show that increased Jun N-terminal kinase (JNK) signaling resulting from the loss of scribble promotes the movement of transformed cells to secondary sites. This effect requires Fos-dependent transcriptional ...[more]