Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.
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ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC1636621 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Publications
Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.
Liu Wei W Lagutin Oleg V OV Mende Michael M Streit Andrea A Oliver Guillermo G
The EMBO journal 20061026 22
The homeobox gene Six3 regulates forebrain development. Here we show that Six3 is also crucial for lens formation. Conditional deletion of mouse Six3 in the presumptive lens ectoderm (PLE) disrupted lens formation. In the most severe cases, lens induction and specification were defective, and the lens placode and lens were absent. In Six3-mutant embryos, Pax6 was downregulated, and Sox2 was absent in the lens preplacodal ectoderm. Using ChIP, electrophoretic mobility shift assay, and luciferase ...[more]
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