Ontology highlight
ABSTRACT:
SUBMITTER: Loughman JA
PROVIDER: S-EPMC1636624 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Loughman Jennifer A JA Caparon Michael G MG
The EMBO journal 20061026 22
Regulation of virulence factor expression is critical for pathogenic microorganisms that must sense and adapt to a dynamic host environment; yet, the signal transduction pathways that enable this process are generally poorly understood. Here, we identify LacD.1 as a global regulator of virulence factor expression in the versatile human pathogen, Streptococcus pyogenes. LacD.1 is derived from a class I tagatose-1,6-bisphosphate aldolase homologous to those involved in lactose and galactose metabo ...[more]